An abscess is a collection of pus underneath the skin or inside your body. Abscesses usually form because of an infection or because a foreign object becomes trapped in your body. The vast majority of them are caused by infections. Inside, they are full of pus, bacteria and debris. Abscesses develop as a result of the interaction between invading micro-organisms and host immune defences. Abscesses can form in almost any part of the body. The skin, under the skin, and the teeth are the most common sites. Abscesses may be caused by bacteria, parasites, and foreign substances. Abscesses in the skin are easy to see. They are red, raised, and painful. Abscesses in other areas of the body may not be seen, but they may cause organ damage.
Types and locations of abscesses include:
Unlike other infections, antibiotics alone will not usually cure an abscess. In general an abscess must open and drain in order for it to improve. Sometimes draining occurs on its own, but generally it must be opened with the help of a warm compress or by a doctor in a procedure called incision and drainage (I&D). Animal models of intraperitoneal and subcutaneous abscesses have proved useful in the study of biological events in the abscess and for the evaluation of antimicrobial agents.
Figure 1. The structure of skin abscess.
Creative Diagnostics has established several animal models of abscess models infections using Staphylococcus aureus and Pseudomonas aeruginosa, including the use of bioluminescent strains for in-life analysis of bacterial infections at the abscess site. The wound can be cut by enumerating CFU (A colony-forming unit, it is a unit used in microbiology to estimate the number of viable bacteria or fungal cells in a sample.) in homogeneous tissue to determine the bacterial load, and biopsy tissue can be removed for pathological examination.
Organisms involved in an abdominal abscess include the following:
We have established models of abscess infection in mice, guinea pigs, rats and rabbits. Among them, taking mice as an example, 50μL bacteria was injected into the side of the right back of the mouse, abscess lesion sizes were measured using a caliper every 24 h for a maximum of 5 days, and then observe and analyze it to evaluate the antibacterial effect of the candidate. Each research parameter (animal strains, pathogens, comparators and dosing schedules, etc.) in the process can be customized to perfectly meet all the needs of the customer's research project.
Creative Diagnostics is a full-service contract research organization specializing in microbiology and preclinical infectious disease research. The correct animal model provides unlimited possibilities for drug discovery and human health advancement. At Creative Diagnostics, we believe that providing clients with the best animal model solutions is the most effective way to promote key research from creativity to reality. We guarantee that the animal models required in research are strictly regulated to ensure responsible, ethical, and humane treatment.