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Adeno-associated Virus (AAV) Neutralizing Antibody Testing

Adeno-associated-Virus-AAV-Neutralizing-Antibody-Testing

Adeno-associated virus (AAV) is one of the most promising viral vectors in scientific research and gene therapy field due to its high tissue specificity, good diffusivity, low immunogenicity, high safety and stability. There are many types of AAV capsid proteins. AAV2 and AAV9 are the most popular backbones for gene therapy, which have been used in clinical practice. Although couple AAV based gene therapeutic products are approved, the ubiquitous neutralizing antibodies against the AAV in experimental animals and human populations can block AAV transduction, leading the failure of therapy.  Therefore, to improve the effectiveness of AAV treatment, it is essential to detect the presence of AAV neutralizing antibodies in subjects or animals in advance, which has guiding significance for the applicability of AAV serotypes in clinical or preclinical trials.

Creative Diagnostics provides the service of detecting specific serotype AAVs neutralizing antibodies in vitro, referring the choices of animal models or AAV serotypes. AAV-2 and AAV-9 neutralization antibody ELISA based tests are available. The neutralization antibody level of the sample accords to the luminescence value RLU of Luciferase, indicating serum/antibody has neutralizing activity against the AAV virus of this serotype. We provide qualitative detection and quantitative detection.

Our Adeno-associated Virus Neutralizing Antibody (NAb) Assays

  • ELISA based assay: AAV-2 and AAV-9 serotypes
  • Cell based assay: AAV-2 and AAV-9 serotypes

Why Use Our AAV Antibody Testing Services?

  • Two assays available to measure neutralizing antibodies qualitatively and quantitatively
  • Rapid turnaround time, with sample testing time in just two weeks
  • Superior quality and competitive pricing
  • We accept samples from anywhere in the world every day
  • May be able to transfer client's custom assays in-house to perform routine screening

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We Are Providing Our Clients Antiviral & Antibacterial Services

Having extensive knowledge in cell biology and the application of cell-based assays to benefit clients in the drug and vaccine development industry

Offering comprehensive solutions to drive your projects to completion

Delivering prompt quotations and competitive prices

Providing quality science and personalized customer service

Antiviral Services - Creative Diagnostics

Creative Diagnostics provides expertise in antiviral (or antibacterial) assays and cell-based antiviral (or antibacterial) compound screening to other biotechnology and pharmaceutical companies.

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