Pathogenic dermatophytes cause superficial mycosis of animal and human skin, called dermatophytosis. Dermatophytosis is a common disease and a worldwide disease, and its incidence is still rising. Dermatophytes are filamentous fungi capable of digesting keratin. According to the keratin substrates they use, they are divided into three different ecological groups (human or animal, dead or alive). The geophilic dermatophytes live in the soil, and they only cause disease sporadically. Anthropophilic and zoophilic species naturally colonize humans and animals, respectively. Most treatments used to fight dermatophytes include azoles that cause liver side effects when administered systemically. Therefore, immune prevention is considered an attractive option. To evaluate the effects of antifungal compounds and vaccines, animal models of dermatophytosis need to be used.
Dermatophytes can be developed in both humans and animals, but the clinical features are different. The zoophilic group of dermatophytes is the most causative agent of human and animal dermatophytosis. Humans are prone to get dermatophytes when they come into contact with different types of animals, such as cats, dogs, guinea pigs, and rabbits. Therefore, selecting animals as models for dermatophytes infection will increase the success rate of developing new drugs. An important stage in testing the potential of chemicals as antifungal drug candidates is to establish their effectiveness in animal model systems. A useful animal model system should be clinically relevant, experimentally robust, ethically acceptable, easy to operate, and should provide reliable and reproducible results.
Creative Diagnostics believes that animal models are very useful for studying human diseases because there are hundreds of pathogens that can affect humans and animals. The use of laboratory animals in biomedical research is a key factor in the development of new prevention methods and the treatment of infectious and non-communicable diseases. Our experienced professional team can provide standard in vivo prediction models of dermatophytosis disease for drug discovery and treatment efficacy studies that need to be developed and validated.
Creative Diagnostics is a full-service contract research organization specializing in microbiology and preclinical infectious disease research. The correct animal model provides unlimited possibilities for drug discovery and human health advancement. At Creative Diagnostics, we believe that providing clients with the best animal model solutions is the most effective way to promote key research from creativity to reality. We guarantee that the animal models required in research are strictly regulated to ensure responsible, ethical, and humane treatment.