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Dermatophytosis Model

Dermatophytosis Model

Pathogenic dermatophytes cause superficial mycosis of animal and human skin, called dermatophytosis. Dermatophytosis is a common disease and a worldwide disease, and its incidence is still rising. Dermatophytes are filamentous fungi capable of digesting keratin. According to the keratin substrates they use, they are divided into three different ecological groups (human or animal, dead or alive). The geophilic dermatophytes live in the soil, and they only cause disease sporadically. Anthropophilic and zoophilic species naturally colonize humans and animals, respectively. Most treatments used to fight dermatophytes include azoles that cause liver side effects when administered systemically. Therefore, immune prevention is considered an attractive option. To evaluate the effects of antifungal compounds and vaccines, animal models of dermatophytosis need to be used.

Dermatophytes can be developed in both humans and animals, but the clinical features are different. The zoophilic group of dermatophytes is the most causative agent of human and animal dermatophytosis. Humans are prone to get dermatophytes when they come into contact with different types of animals, such as cats, dogs, guinea pigs, and rabbits. Therefore, selecting animals as models for dermatophytes infection will increase the success rate of developing new drugs. An important stage in testing the potential of chemicals as antifungal drug candidates is to establish their effectiveness in animal model systems. A useful animal model system should be clinically relevant, experimentally robust, ethically acceptable, easy to operate, and should provide reliable and reproducible results.

Creative Diagnostics believes that animal models are very useful for studying human diseases because there are hundreds of pathogens that can affect humans and animals. The use of laboratory animals in biomedical research is a key factor in the development of new prevention methods and the treatment of infectious and non-communicable diseases. Our experienced professional team can provide standard in vivo prediction models of dermatophytosis disease for drug discovery and treatment efficacy studies that need to be developed and validated.

Our Procedures

  • Animal modeling
  • Antifungal treatment
  • Clinical evaluation
  • Mycological evaluation including microscopy and culture, and histopathology

Our Services

  • Dermatophytosis disease animal model development
    • Strains: Trichophyton rubrum, Trichophyton mentagrophytes, and Microsporum canis.
    • Types: tinea corporis models, tinea pedis models and tinea unguium models.
    • Animal species: cockscomb, mouse (BALB/c, AKR, C3H, DBA/2, (CBA×DBA/2)F1, CBA, and C57BL/6), nude rats, rabbits, chickens, and guinea pigs.
  • Determination of efficacy of antifungal compounds in dermatophytosis; accurately evaluate the antifungal agent in vivo
  • Study of immunity of antifungal compounds against dermatophytes
  • Study of dermatophyte pathogenicity

Our Advantages

  • High infection rate
  • Introduction of an infected animal in a group of naïve congeners to perfectly mimic a natural infection
  • Full report and timely result delivery

Creative Diagnostics is a full-service contract research organization specializing in microbiology and preclinical infectious disease research. The correct animal model provides unlimited possibilities for drug discovery and human health advancement. At Creative Diagnostics, we believe that providing clients with the best animal model solutions is the most effective way to promote key research from creativity to reality. We guarantee that the animal models required in research are strictly regulated to ensure responsible, ethical, and humane treatment.

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We Are Providing Our Clients Antiviral & Antibacterial Services

Having extensive knowledge in cell biology and the application of cell-based assays to benefit clients in the drug and vaccine development industry

Offering comprehensive solutions to drive your projects to completion

Delivering prompt quotations and competitive prices

Providing quality science and personalized customer service

Antiviral Services - Creative Diagnostics

Creative Diagnostics provides expertise in antiviral (or antibacterial) assays and cell-based antiviral (or antibacterial) compound screening to other biotechnology and pharmaceutical companies.

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