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Fungemia Model

Fungemia model is a disease in which fungi or yeasts exist in the blood. The most common type is Candida, or systemic candidiasis, which is a disease caused by infection with Candida species. Candidiasis is also the most common blood infection. Infections with other fungi (including Saccharomyces cerevisiae, Aspergillus and Cryptococcus) are also called fungal diseases. Infections are most common in immunosuppressed or immunocompromised patients, patients with severe neutropenia, cancer patients, or patients with intravenous catheters.

Further research found that the most common pathogen in mycemia is Candida albicans, which causes about 70% of fungal diseases, followed by Candida glabrata, Aspergillus, and Saccharomyces cerevisiae. However, recent studies have found that the frequency of infections of Chlorella glabrata, Saccharomyces boulardii, Candida tropicalis, Kluyveromyces and Parapsilosis is increasing. This may be due to the high use of fluconazole or antibiotics.

In the blood, as these fungi multiply, a potentially life-threatening infection will develop, called sepsis. These conditions stem from fungi elsewhere in the body. These symptoms are caused by the intermittent or continuous release of fungus into the bloodstream from other parts of the body, including the lungs, abdomen, and urethra. Therefore, corresponding drugs are needed to treat infections clinically. Creative Diagnostics has established an animal disease model for fungemia research to determine the efficacy of new therapies.

Program

We have established a fungemia model in mice (rat verification is available upon request). We inject a certain dose of fungal infection on the animals by intravenous injection (IV) into the lateral tail vein of the mouse. After confirming that the infection model is established, the test candidate drug can be administered by gavage (PO) or subcutaneous (SC), intravenous (IV) or intraperitoneal (IP) injection. In this process, we can customize each research parameter (animal strain, pathogen, comparator and dosing schedule) to meet the needs of customers.

Our Services

The study's endpoints include mortality tracking, clinical observation, and CFU burden in organs, and/or blood.

  • Build customizable infection models
  • Provide in vivo antimicrobial evaluation services
  • Detect changes in CFU burden in organs and/or blood
  • Exposure-Response studies
  • Infected and non-infected blood/tissue PK studies (i.e. Brain, lung, soft tissue, and bone)
  • Single- and multiple-dose PK studies
  • Dose fractionation studies
  • Time course studies
  • Blood chemistry
  • Other tissue harvest and histological analysis

Pathogens

Creative Diagnostics has validated a fungemia model using the following pathogens:

  • Aspergillus Fumigatus (ATCC 3073)
  • Candida albicans (ATCC SC5314)

Creative Diagnostics is a full-service contract research organization specializing in microbiology and preclinical infectious disease research. The correct animal model provides unlimited possibilities for drug discovery and human health advancement. At Creative Diagnostics, we believe that providing clients with the best animal model solutions is the most effective way to promote key research from creativity to reality. We guarantee that the animal models required in research are strictly regulated to ensure responsible, ethical, and humane treatment.

Services

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We Are Providing Our Clients Antiviral & Antibacterial Services

Having extensive knowledge in cell biology and the application of cell-based assays to benefit clients in the drug and vaccine development industry

Offering comprehensive solutions to drive your projects to completion

Delivering prompt quotations and competitive prices

Providing quality science and personalized customer service

Antiviral Services - Creative Diagnostics

Creative Diagnostics provides expertise in antiviral (or antibacterial) assays and cell-based antiviral (or antibacterial) compound screening to other biotechnology and pharmaceutical companies.

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