The gastrointestinal tract model is an experimental system that can reproduce all aspects of the human digestive system to study its function in digestion and disease. They include animal models, such as mouse genetic models of intestinal diseases and in vitro chemical systems that summarize digestion, and animal infection models, such as intestinal epithelial and intestinal microbial infection models.
Gastrointestinal infections involve the stomach and small intestine. Many pathogens can cause simple and/or secretory diarrhea, and severe cases can cause dehydration, sepsis and even death. Under normal physiological conditions, the gastrointestinal tract is not easily infected by microorganisms due to its own protective mechanism and intestinal flora. However, when the body is treated with broad-spectrum antibiotics, antibiotics will destroy the intestinal flora and reduce the intestinal anti-infection ability, which provides opportunities for pathogenic microorganisms to infect. Therefore, there is a clinical need for drugs or methods that can provide antibacterial protection for the gastrointestinal tract. In order to evaluate the efficacy of new antibacterial drugs on gastrointestinal diseases, Creative Diagnostics established a mouse gastrointestinal colonization and infection model.
We have established a gastrointestinal infection model in mice, in which the animal is infected with pathogens by oral gavage (PO). The infected animal model is exposed to spectrum antibiotics by drinking water containing a mixture of antibiotics, thereby destroying the intestinal flora and increasing the susceptibility to infection. The candidate compound can be administered by oral (PO) or perirectal (PR) administration, subcutaneous (SC), intravenous (IV) or intraperitoneal (IP) injection, or by diet or drinking water. During the experiment, you can customize each research parameter (animal strain, pathogen, comparator, dosing schedule) to meet the various needs of your project.
Creative Diagnostics has validated gastrointestinal models with the following pathogens:
The study's endpoints include mortality tracking, clinical observation, weight tracking, and CFU burden in feces, organs, and/or blood.
Creative Diagnostics is a full-service contract research organization specializing in microbiology and preclinical infectious disease research. The correct animal model provides unlimited possibilities for drug discovery and human health advancement. At Creative Diagnostics, we believe that providing clients with the best animal model solutions is the most effective way to promote key research from creativity to reality. We guarantee that the animal models required in research are strictly regulated to ensure responsible, ethical, and humane treatment.