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Gastrointestinal Model

The gastrointestinal tract model is an experimental system that can reproduce all aspects of the human digestive system to study its function in digestion and disease. They include animal models, such as mouse genetic models of intestinal diseases and in vitro chemical systems that summarize digestion, and animal infection models, such as intestinal epithelial and intestinal microbial infection models.
Gastrointestinal infections involve the stomach and small intestine. Many pathogens can cause simple and/or secretory diarrhea, and severe cases can cause dehydration, sepsis and even death. Under normal physiological conditions, the gastrointestinal tract is not easily infected by microorganisms due to its own protective mechanism and intestinal flora. However, when the body is treated with broad-spectrum antibiotics, antibiotics will destroy the intestinal flora and reduce the intestinal anti-infection ability, which provides opportunities for pathogenic microorganisms to infect. Therefore, there is a clinical need for drugs or methods that can provide antibacterial protection for the gastrointestinal tract. In order to evaluate the efficacy of new antibacterial drugs on gastrointestinal diseases, Creative Diagnostics established a mouse gastrointestinal colonization and infection model.

Our Procedures

We have established a gastrointestinal infection model in mice, in which the animal is infected with pathogens by oral gavage (PO). The infected animal model is exposed to spectrum antibiotics by drinking water containing a mixture of antibiotics, thereby destroying the intestinal flora and increasing the susceptibility to infection. The candidate compound can be administered by oral (PO) or perirectal (PR) administration, subcutaneous (SC), intravenous (IV) or intraperitoneal (IP) injection, or by diet or drinking water. During the experiment, you can customize each research parameter (animal strain, pathogen, comparator, dosing schedule) to meet the various needs of your project.

Pathogen

Creative Diagnostics has validated gastrointestinal models with the following pathogens:

  • Escherichia coli
  • Clostridium difficile
  • Enterococcus faecalis
  • Enterococcus faecium
  • Salmonella enterica serovar Typhimurium

Our Services

The study's endpoints include mortality tracking, clinical observation, weight tracking, and CFU burden in feces, organs, and/or blood.

  • Build customizable infection models
  • Provide in vivo antimicrobial evaluation services
  • Detect changes in CFU burden in feces, organs and/or blood
  • Exposure-Response Studies
  • Infected and non-infected blood/tissue PK studies (i.e. Brain, lung, soft tissue, and bone)
  • Single- and multiple-dose PK studies
  • Dose fractionation studies
  • Time course studies
  • Blood chemistry
  • Other tissue harvest and histological analysis

Our Advantages

  • Ensure high efficiency and quality for gastrointestinal model services
  • Competitive price in the market of gastrointestinal model services
  • Ensure 24/7 online service
  • Timely result feedback

Creative Diagnostics is a full-service contract research organization specializing in microbiology and preclinical infectious disease research. The correct animal model provides unlimited possibilities for drug discovery and human health advancement. At Creative Diagnostics, we believe that providing clients with the best animal model solutions is the most effective way to promote key research from creativity to reality. We guarantee that the animal models required in research are strictly regulated to ensure responsible, ethical, and humane treatment.

Services

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We Are Providing Our Clients Antiviral & Antibacterial Services

Having extensive knowledge in cell biology and the application of cell-based assays to benefit clients in the drug and vaccine development industry

Offering comprehensive solutions to drive your projects to completion

Delivering prompt quotations and competitive prices

Providing quality science and personalized customer service

Antiviral Services - Creative Diagnostics

Creative Diagnostics provides expertise in antiviral (or antibacterial) assays and cell-based antiviral (or antibacterial) compound screening to other biotechnology and pharmaceutical companies.

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