The etiological agents of STIs are bacteria, protozoans, viruses and chlamydias among which are: Neisseria gonorrhoeae, Treponema pallidum, Trichomonas vaginalis, Chlamydia trachomatis, human immunodeficiency virus (HIV), herpes simplex virus 2 (HSV-2), human papillomavirus (HPV) and hepatitis B virus (HBV).
The design of an effective vaginal microbicide requires understanding the steps that the viruses follow to establish infection in the female genital tract. A series of in vitro models have been described in the literature to assess preclinical safety in exploratory studies but require in vivo models to further validation. The mucosal delivery of vaginal microbicides demands a close look at the integrity of cervicovaginal mucosa and the possible development of inflammatory processes after microbicide application. Breaks in the integrity of the mucosa and inflammatory conditions will create an ideal environment for the establishment of STIs.
The intravaginal infection model is to use infection methods to cause a certain degree of damage to the animal’s vaginal. Study these changes in the function, metabolism, morphology and structure of diseases, or various diseases, use this method to study the occurrence and development of human diseases, and provide a theoretical basis for studying the prevention and treatment of women's diseases.
Figure 1. Estrus- and Diestrus-like Vaginal Histopathology and Immunohistochemical Detection of ZIKV Protein NS2B in Diestrus-like AG129 Mice with Intravaginal ZIKV Infection
(Tang et al., 2016, Cell Reports 17, 3091–3098)
Creative Diagnostics has established several different Intravaginal infection models ranging from bacteria such as Candida albicans, Neisseria gonorrhoeae to virus such as Human immunodeficiency virus (HIV),Herpes simplex virus 2 (HSV-2), Human papillomavirus (HPV),Hepatitis B virus (HBV).
Organisms involved in an intravaginal infection include the following:
We have a range of intravaginal infection models suitable for your unique research needs. These models monitor changes in pH, microflora, inflammatory infiltrates on tissues, cytokines and chemokine levels in vaginal swabs, measuring the overall health of the vaginal mucosa.
Creative Diagnostics is a full-service contract research organization specializing in microbiology and preclinical infectious disease research. The correct animal model provides unlimited possibilities for drug discovery and human health advancement. At Creative Diagnostics, we believe that providing clients with the best animal model solutions is the most effective way to promote key research from creativity to reality. We guarantee that the animal models required in research are strictly regulated to ensure responsible, ethical, and humane treatment.