Osteomyelitis Model
Musculoskeletal infections, especially osteomyelitis, place a huge burden on patients, doctors, and the entire health care system. Osteomyelitis is an acute or chronic inflammatory process of bone and related structures secondary to purulent microbial infection. Although there are many animal osteomyelitis models for the study of acute and chronic osteomyelitis, the search for ideal models continues.
Osteomyelitis can be divided into three groups: hematogenous osteomyelitis, contiguous osteomyelitis, and osteomyelitis associated with peripheral vascular disease. The manifestations of osteomyelitis are diverse, and some confounding variables, such as the low incidence of osteomyelitis, multiple pathogens, antibiotic sensitivity, and the anatomical location of the disease, also prevent these classifications from being controllable in clinical research. Several animal osteomyelitis models have been established for in vivo study. Researchers can use various animals to build models to study different osteomyelitis types and stages. Smaller animals are easy to handle and cost-effective, but they cannot withstand the limitations of therapeutic antibiotic doses and multiple surgeries. Larger animals are more tolerant of therapeutic antibiotic doses and multiple procedures but are limited by availability, increased costs, and potential aggressiveness.
Creative Diagnostics believes that animal models are very useful for studying human diseases because in vitro studies cannot reflect the full range of anatomical and physiological effects. The use of laboratory animals in biomedical research is a key factor in the development of new prevention methods and the treatment of infectious and non-communicable diseases. Our experienced professional team can provide standard in vivo prediction models of peritonitis for drug discovery and treatment efficacy studies that need to be developed and validated.
Our Procedures
- Selection of bacterial strain and inoculum
- Preparation of animals and operation
- Examination: clinical observation, radiography, microbiology, histology, etc
- Analysis
Our Services
- Osteomyelitis model development
- Stains: Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Staphylococcus pyogenes, Escherichia coli, Bacteroides thetaiotaoicron, Bacteroides fragilis, Bacteroides melaninogenicus, etc.
- Types: acute or chronic osteomyelitis (tibia, femur, radius, spine, mandible, hematogenous).
- Routes of inoculation: local inoculation into the bone cavity, local inoculation through nutrient arteries, and systemic inoculation through intravenous injection.
- Animal species: mouse, rat, guinea pig, chicken, rabbit, dog, pig, goat and sheep.
- Evaluation includes clinical observation, radiography, microbiology, and histology. High temperature, lethargy, and weight loss may indicate the development of bony infection, soft tissue infection, or generalized sepsis.
Our Advantages
- Custom animal model development
- Comprehensive evaluation of drug candidates
- Various inoculation routes available
- Full report and timely result delivery
Creative Diagnostics is a full-service contract research organization specializing in microbiology and preclinical infectious disease research. The correct animal model provides unlimited possibilities for drug discovery and human health advancement. At Creative Diagnostics, we believe that providing clients with the best animal model solutions is the most effective way to promote key research from creativity to reality. We guarantee that the animal models required in research are strictly regulated to ensure responsible, ethical, and humane treatment.
