Peritonitis Model
Peritoneal inflammation-peritonitis-is divided into primary peritonitis and secondary peritonitis. Primary peritonitis is caused by bacterial translocation, blood-borne spread, or iatrogenic contamination of the abdomen, and there is no macroscopic defect in the gastrointestinal tract. In contrast, secondary peritonitis is caused by the spillage of the gastrointestinal or urogenital tract or its related solid organs directly contaminating the peritoneum. Tertiary peritonitis refers to secondary peritonitis that lasts more than 48 hours after attempting surgical source control.
Understanding the role of pathogens and endotoxins in peritonitis and its complications may improve the accuracy of diagnosis and formulate treatment plans. The etiology of peritonitis is multi-factorial, affecting the cardiovascular, immune, and endocrine systems of the human body. Animal models are an important contributor in evaluating the effectiveness and safety of potentially therapeutic drugs. However, their physiological limitations often limit their use and create barriers to translating research results into clinical practice. Therefore, carefully distinguishing the models can help to study different aspects of this disease and successfully convert these results into clinical trials.
Creative Diagnostics believes that animal models are very useful for studying human diseases because in vitro studies cannot reflect the full range of anatomical and physiological effects. The use of laboratory animals in biomedical research is a key factor in the development of new prevention methods and the treatment of infectious and non-communicable diseases. Our experienced professional team can provide standard in vivo prediction models of peritonitis for drug discovery and treatment efficacy studies that need to be developed and validated.
Our Procedures
- Consult our experienced team and cooperate to build a customized model
- Efficiently measure preclinical drug efficacy and model response to treatment
- Evaluation of anti-inflammatory compounds
Our Services
- Peritonitis media animal model development
- Strains & methods: Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Candida albicans, lipopolysaccharide, peritoneal dialysis fluid, scraping, methylglyoxal, chlorhexidine, etc.
- Types: infectious model & non-infectious model.
- Animal species: rat, mouse, etc.
- Evaluate the acute inflammatory response mediated by the agent inflammasome
- Evaluate the ability of the formulation to reduce the acute TLR-activated inflammation associated with peritonitis
- Accurately study the effects of your compounds on various immune components
- Use flow cytometry to analyze the cells of interest
- ELISA or MSD method to measure cytokine levels
- qPCR to measure inflammatory gene expression of recruited leukocytes
Our Advantages
- Custom animal model development
- Comprehensive evaluation of drug candidates
- Full report and timely result delivery
Creative Diagnostics is a full-service contract research organization specializing in microbiology and preclinical infectious disease research. The correct animal model provides unlimited possibilities for drug discovery and human health advancement. At Creative Diagnostics, we believe that providing clients with the best animal model solutions is the most effective way to promote key research from creativity to reality. We guarantee that the animal models required in research are strictly regulated to ensure responsible, ethical, and humane treatment.
