Pulmonary Model

With the aging of the population and the aggravation of environmental pollutants (including tobacco smoke), the health effects on human lung tissues are becoming more and more serious. Airway diseases such as chronic lung inflammation (including chronic obstructive pulmonary disease and asthma) are harmful Human health is causing more and more damage. The causes of these problems are induced by pro-inflammatory molecules that respond to acute infections, but they usually lead to chronic immune responses that induce acute crises and damage of lung tissue over time.

The lung inflammation is usually caused by inhaled pathogens. Pneumonia is a common disease clinically and is usually easier to treat, but in some individuals with compromised immune systems, more severe symptoms usually occur. Although current therapies are generally able to combat deadly diseases, the emergence of antimicrobial-resistant strains of bacteria requires further research to identify novel therapies. Creative Diagnostics has established a lung research platform that can screen candidates with antimicrobial activity for infections in the body to quickly determine the most promising clinical therapies.

Program

We have established lung infection models in mice and rats, in which animals are infected with pathogens by intranasal (IN) or intratracheal (IT) instillation. After the infection is complete, it can be through nebulization, oral tube feeding (PO), intranasal (IN) or intratracheal (IT) drip or intravenous (IV), intraperitoneal (IP), intramuscular (IM) or subcutaneous (SC) Animal testing of candidate antibacterial drugs by injection. In this process, we can provide customized services for each research parameter (animal strain, pathogen, comparator and dosing schedule) to meet customer needs.

Our Services

The study's endpoints include mortality tracking, clinical observation, and CFU burden in organs, and/or blood.

• Build customizable infection models
• Provide in vivo antimicrobial evaluation services
• Detect changes in CFU burden in organs and/or blood
• Exposure-Response studies
• Infected and non-infected blood/tissue PK studies (i.e. Brain, lung, soft tissue, and bone)
• Single- and multiple-dose PK studies
• Dose fractionation studies
• Time course studies
• Blood chemistry
• Other tissue harvest and histological analysis

Pathogens

Creative Diagnostics has validated a pulmonary model using the following pathogens:

• Acinetobacter baumannii (ATCC 17961)
• Aspergillus fumigatus (ATCC 13073)
• Cryptococcus neoformans (ATCC 24067)
• Haemophilus influenzae (54A1218, non-typeable)
• Klebsiella pneumoniae (ATCC 43816)
• Pseudomonas aeruginosa (ATCC 15692, ATCC 27853)
• Staphylococcus aureus (MRSA) (ATCC 33591, ATCC BAA-1556, USA300)
• Streptococcus pneumoniae (ATCC 10813, ATCC 70067, D39, SV-1, 402J1095)

Our Advantages

• Ensure high efficiency and quality for pulmonary model services
• Competitive price in the market of pulmonary model services
• Ensure 24/7 online service
• Timely result feedback

Creative Diagnostics is a full-service contract research organization specializing in microbiology and preclinical infectious disease research. The correct animal model provides unlimited possibilities for drug discovery and human health advancement. At Creative Diagnostics, we believe that providing clients with the best animal model solutions is the most effective way to promote key research from creativity to reality. We guarantee that the animal models required in research are strictly regulated to ensure responsible, ethical, and humane treatment.