The skin is the human body's first defense system. It usually prevents microorganisms in the environment from entering the human body. But when there is a wound on the skin, microorganisms will enter through the wound and cause skin infection. Abrasions, also called cuts or "brush burns," refer to mild injuries that occur when the skin is rubbed or torn. It is a shallow wound that usually wears the top layer of the skin (the epidermis) due to friction applied to the body. The scraped surface layer of the skin caused by abrasions may contain dust particles. If not cleaned and maintained, it may cause dermal infections or other complications.
Dermal infections involve the dermis, the dense inner layer of skin under the epidermis. These skin infections are caused by microbial invasion, and the manifestation and severity of the infection vary with the treatment time, the invading pathogen and the immune response it causes. In severe cases, skin infections can progress to the underlying soft tissues or become systemic infections. Skin infections are caused by different kinds of microorganisms. It is known that bacteria cause cellulitis, impetigo and staphylococcal (Staphylococcus) infections; viruses cause herpes zoster, warts and herpes simplex; fungi cause athlete's foot and yeast infections. Therefore effective anti-infective drugs Is a must. For research and anti-infective drug screening, similar animal infection models are very important.
In order to evaluate the pharmacodynamic relationship between new antibacterial drugs and infection results, Creative Diagnostics established a mouse skin (sandpaper) infection model. In order to remove the outermost epidermis of the skin, sandpaper is used to abrade the back area, and then the animal is locally inoculated with an infectious agent. The test article can be administered locally, orally by intragastric (PO), subcutaneous (SC), intraperitoneal (IP) or intravenous (IV) injection. Each study parameter (animal strain, pathogen, comparator and dosing plan) can be customized according to customer needs.
The endpoints of the model are the clinical score of the spread of herpes simplex virus infection and the score of the CFU burden of bacterial infection of harvested skin. Build customizable infection models
Creative Diagnostics is a full-service contract research organization specializing in microbiology and preclinical infectious disease research. The correct animal model provides unlimited possibilities for drug discovery and human health advancement. At Creative Diagnostics, we believe that providing clients with the best animal model solutions is the most effective way to promote key research from creativity to reality. We guarantee that the animal models required in research are strictly regulated to ensure responsible, ethical, and humane treatment.